Article
How does genotype influence disease phenotype in inflammatory bowel disease?
Inflammatory bowel diseases - 1 Aug 2013
Ananthakrishnan Ashwin N, Xavier Ramnik J
Abstract excerpt
Inflammatory bowel diseases (Crohn's disease and ulcerative colitis) are chronic immunologically mediated diseases of the gut. Advances in genetics have revolutionized our understanding of the pathogenesis of these conditions with 163 risk loci identified, encompassing a variety of immunologic functions. There is substantial heterogeneity in the natural history of these diseases with respect to disease onset,...
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