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Article

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.

Gut - 1 Oct 2013

Knights Dan, Lassen Kara G, Xavier Ramnik J

Abstract excerpt

Studies of the genetics underlying inflammatory bowel diseases have increased our understanding of the pathways involved in both ulcerative colitis and Crohn's disease and focused attention on the role of the microbiome in these diseases. Full understanding of pathogenesis will require a comprehensive grasp of the delicate homeostasis between gut bacteria and the human host. In this review, we present current...

Topics

Bacteria
Genetic Predisposition to Disease
Host-Pathogen Interactions
Humans
Inflammatory Bowel Diseases
Intestines
Microbiota
Phenotype
Signal Transduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24037875
DOI: 10.1136/gutjnl-2012-303954
PMCID: PMC3822528

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