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Article

Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology.

The Journal of pathology - 1 Apr 2018

McCart Reed Amy E, Kutasovic Jamie R, Nones Katia, Saunus Jodi M, Da Silva Leonard, Newell Felicity, Kazakoff Stephen, Melville Lewis, Jayanthan Janani, Vargas Ana Cristina, Reid Lynne E, Beesley Jonathan, Chen Xiao Qing, Patch Anne-Marie, Clouston David, Porter Alan, Evans Elizabeth, Pearson John V, Chenevix-Trench Georgia, Cummings Margaret C, Waddell Nicola, Lakhani Sunil R, Simpson Peter T

Abstract excerpt

Mixed ductal-lobular carcinomas (MDLs) show both ductal and lobular morphology, and constitute an archetypal example of intratumoural morphological heterogeneity. The mechanisms underlying the coexistence of these different morphological entities are poorly understood, although theories include that these components either represent 'collision' of independent tumours or evolve from a common ancestor. We performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29344954
DOI: 10.1002/path.5040
PMCID: PMC5873281

Genes

BRCA2
CDH1
ESR1
TBX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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