Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells

16 Jan 2018

Abstract excerpt

The transcription factor c-MYC regulates a multiplicity of genes involved in cellular growth, proliferation, metabolism and DNA damage response and its overexpression is a hallmark of many tumours. Since MYC promotes apoptosis under conditions of stress, such as limited availability of nutrients or cytokines, MYC-driven cells are very much dependent on signals that inhibit cell death. Stress signals trigger...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29339775
DOI: 10.1038/s41418-017-0045-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cellsPMID 29339775Read ↗

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.Semantic proximity Read ↗

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.Semantic proximity Read ↗

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemiaSemantic proximity Read ↗

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Semantic proximity Read ↗

c-MYC: more than just a matter of life and death.Semantic proximity Read ↗

MNT loss in MYC-driven B lymphoma cells enhances apoptosis, inhibits proliferation and increases sensitivity to cancer drugsSemantic proximity Read ↗

MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice.Semantic proximity Read ↗

The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survivalSemantic proximity Read ↗

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stressSemantic proximity Read ↗

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.Semantic proximity Read ↗

Last but not least: BFL-1 as an emerging target for anti-cancer therapiesSemantic proximity Read ↗

Myc Roles in Hematopoiesis and LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.