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Article

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

Nature - 22 Nov 1990

Strasser A, Harris A W, Bath M L, Cory S

Abstract excerpt

The putative oncogene bcl-2 is juxtaposed to the immunoglobulin heavy chain (Igh) locus by the t(14;18) chromosomal translocation typical of human follicular B-cell lymphomas. The bcl-2 gene product is not altered by the translocation, but its expression is deregulated, presumably by the Igh enhancer E mu. Constitutive bcl-2 expression seems to augment cell survival, as infection with a bcl-2 retrovirus enables...

Topics

Animals
B-Lymphocytes
Cell Line
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Genes, myc
Humans
Leukocytes
Lymphoma
Mice
Mice, Transgenic
Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-bcl-2

Translocation, Genetic

Source

Identifiers

PMID: 2250704
DOI: 10.1038/348331a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2250704-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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