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Article

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

Nature - 22 Nov 1990

Strasser A, Harris A W, Bath M L, Cory S

Abstract excerpt

The putative oncogene bcl-2 is juxtaposed to the immunoglobulin heavy chain (Igh) locus by the t(14;18) chromosomal translocation typical of human follicular B-cell lymphomas. The bcl-2 gene product is not altered by the translocation, but its expression is deregulated, presumably by the Igh enhancer E mu. Constitutive bcl-2 expression seems to augment cell survival, as infection with a bcl-2 retrovirus enables...

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Identifiers

PMID: 2250704
DOI: 10.1038/348331a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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