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Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

20 May 2010

Abstract excerpt

Antiapoptotic BCL2 family members have been implicated in the pathogenesis of acute myelogenous leukemia (AML), but the functional significance and relative importance of individual proteins (e.g., BCL2, BCL-XL, and myeloid cell leukemia 1 [MCL1]) remain poorly understood. Here, we examined the expression of BCL2, BCL-XL, and MCL1 in primary human hematopoietic subsets and leukemic blasts from AML patients and...

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PMID: 20484815
DOI: 10.1172/jci39964

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