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Last but not least: BFL-1 as an emerging target for anti-cancer therapies

28 Jul 2022

Abstract excerpt

BFL-1 is an understudied pro-survival BCL-2 protein. The expression of BFL-1 is reported in many cancers, but it is yet to be clarified whether high transcript expression also always correlates with a pro-survival function. However, recent applications of BH3-mimetics for the treatment of blood cancers identified BFL-1 as a potential resistance factor in this type of cancer. Hence, understanding the role of BFL-1...

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PMID: 35900226
DOI: 10.1042/bst20220153

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