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Article

Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors.

Scientific reports - 16 Jan 2018

Burgess J K, Ketheson A, Faiz A, Limbert Rempel K A, Oliver B G, Ward J P T, Halayko A J

Abstract excerpt

Asthma is an obstructive respiratory disease characterised by chronic inflammation with airway hyperresponsiveness. In asthmatic airways, there is an increase in airway smooth muscle (ASM) cell bulk, which differs from non-asthmatic ASM in characteristics. This study aimed to assess the usefulness of hTERT immortalisation of human ASM cells as a research tool. Specifically we compared proliferative capacity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29339735
DOI: 10.1038/s41598-017-18429-0
PMCID: PMC5770384

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