Article
Functional phenotype of airway myocytes from asthmatic airways.
Pulmonary pharmacology & therapeutics - 1 Feb 2013
Wright David B, Trian Thomas, Siddiqui Sana, Pascoe Chris D, Ojo Oluwaseun O, Johnson Jill R, Dekkers Bart G J, Dakshinamurti Shyamala, Bagchi Rushita, Burgess Janette K, Kanabar Varsha
Abstract excerpt
In asthma, the airway smooth muscle (ASM) cell plays a central role in disease pathogenesis through cellular changes which may impact on its microenvironment and alter ASM response and function. The answer to the long debated question of what makes a 'healthy' ASM cell become 'asthmatic' still remains speculative. What is known of an 'asthmatic' ASM cell, is its ability to contribute to the hallmarks of asthma...
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