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Article

Immortalization of human small airway epithelial cells by ectopic expression of telomerase

6 Jan 2005

Abstract excerpt

Two immortalized human airway epithelial cell lines were established by the ectopic expression of human telomerase reverse transcriptase (hTERT). These cell lines have been continuously cultured for >200 population doublings (PDs). They are characterized by an overexpression of hTERT mRNA, elongated telomere length and higher telomerase activity. Early passage of these cells (<20 PDs) expressed the p16 protein at...

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Share to Congenital Anomalies and Fetal Surgery
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PMID: 15677631
DOI: 10.1093/carcin/bgi016

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