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Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signaling

1 Jan 2025

Abstract excerpt

Mast cells (MCs) expressing a distinctive protease phenotype (MCTs) selectively expand within the epithelium of human mucosal tissues during type 2 (T2) inflammation. While MCTs are phenotypically distinct from subepithelial MCs (MCTCs), signals driving human MCT differentiation and this subset's contribution to inflammation remain unexplored. Here, we have identified TGF-β as a key driver of the MCT...

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PMID: 39744949
DOI: 10.1172/jci174981

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