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Article

Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets

30 Aug 2017

Abstract excerpt

Human Mucosal Associated Invariant T (MAIT) cells are an important T cell subset which are enriched in tissues and possess potent effector functions. Typically such cells are marked by their expression of Vα7.2-Jα33/Jα20/Jα12 T cell receptor (TCRs), and functionally they are major histocompatibility complex (MHC) class I-related protein 1 (MR1)-restricted, responding to bacterially-derived riboflavin synthesis...

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Identifiers

PMID: 28912775
DOI: 10.3389/fimmu.2017.01031

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