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Article

Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis.

Genes & development - 1 Dec 2017

Azizoglu D Berfin, Braitsch Caitlin, Marciano Denise K, Cleaver Ondine

Abstract excerpt

Proper lumen morphogenesis during pancreas development is critical to endocrine and exocrine cell fate. Recent studies showed that a central network of lumens (termed core), but not the surrounding terminal branches (termed periphery), produces most islet endocrine cells. To date, it remains unclear how pancreatic lumens form and remodel and which aspects of lumen morphogenesis influence cell fate. Importantly,...

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Identifiers

PMID: 29330353
DOI: 10.1101/gad.307637.117
PMCID: PMC5795784

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