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Heterogeneous murine peribiliary glands orchestrate compartmentalized epithelial renewal

30 Oct 2023

Abstract excerpt

The extrahepatic branches of the biliary tree have glands that connect to the surface epithelium through narrow pits. The duct epithelia undergo homeostatic renewal, yet the identity and multiplicity of cells that maintain this tissue is unknown. Using marker-free and targeted clonal fate mapping in mice, we provide evidence that the extrahepatic bile duct is compartmentalized. Pit cholangiocytes of extramural...

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PMID: 37909044
DOI: 10.1016/j.devcel.2023.10.004

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