Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape.

Development (Cambridge, England) - 1 Dec 2010

Pirraglia Carolyn, Walters Jenna, Myat Monn Monn

Abstract excerpt

Generating and maintaining proper lumen size and shape in tubular organs is essential for organ function. Here, we demonstrate a novel role for p21-activated kinase 1 (Pak1) in defining the size and shape of the Drosophila embryonic salivary gland lumen by regulating the size and elongation of the apical domain of individual cells. Pak1 mediates these effects by decreasing and increasing E-cadherin levels at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dynamins
Share to Endocytosis
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Electron, Transmission

Share to Neurofibromin 2

Share to p21-Activated Kinases

Share to rab5 GTP-Binding Proteins

Share to Salivary Glands

Source

Open in PubMed Open full text

Identifiers

PMID: 21068057
DOI: 10.1242/dev.048827
PMCID: PMC2990209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape.PMID 21068057Read ↗

Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin.Semantic proximity Read ↗

Rac1 GTPase acts downstream of αPS1βPS integrin to control collective migration and lumen size in the Drosophila salivary gland.Semantic proximity Read ↗

Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling.Semantic proximity Read ↗

A targeted gain-of-function screen identifies genes affecting salivary gland morphogenesis/tubulogenesis in Drosophila.Semantic proximity Read ↗

The endo-lysosomal system drives lumen formation in a human epiblast modelSemantic proximity Read ↗

Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.Semantic proximity Read ↗

Salivary gland development and diseaseSemantic proximity Read ↗

COPI vesicle transport is a common requirement for tube expansion in Drosophila.Semantic proximity Read ↗

Two Distinct Integrin-Mediated Mechanisms Contribute to Apical Lumen Formation in Epithelial CellsSemantic proximity Read ↗

Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin.Semantic proximity Read ↗

Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complexSemantic proximity Read ↗

Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.