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Article

Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin.

Development (Cambridge, England) - 1 Dec 2011

Xu Na, Bagumian Gaiana, Galiano Michael, Myat Monn Monn

Abstract excerpt

Generation and maintenance of proper lumen size is important for tubular organ function. We report on a novel role for the Drosophila Rho1 GTPase in control of salivary gland lumen size through regulation of cell rearrangement, apical domain elongation and cell shape change. We show that Rho1 controls cell rearrangement and apical domain elongation by promoting actin polymerization and regulating F-actin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22071107
DOI: 10.1242/dev.069831
PMCID: PMC3222215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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