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Article

Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells.

Nature communications - 3 Aug 2016

Mangan Anthony J, Sietsema Daniel V, Li Dongying, Moore Jeffrey K, Citi Sandra, Prekeris Rytis

Abstract excerpt

Coordinated polarization of epithelial cells is a key step during morphogenesis that leads to the formation of an apical lumen. Rab11 and its interacting protein FIP5 are necessary for the targeting of apical endosomes to the midbody and apical membrane initiation site (AMIS) during lumenogenesis. However, the machinery that mediates AMIS establishment and FIP5-endosome targeting remains unknown. Here we identify...

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Identifiers

PMID: 27484926
DOI: 10.1038/ncomms12426
PMCID: PMC4976216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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