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Article

Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling.

Development (Cambridge, England) - 1 Mar 2014

Alvers Ashley L, Ryan Sean, Scherz Paul J, Huisken Jan, Bagnat Michel

Abstract excerpt

The formation of a single lumen during tubulogenesis is crucial for the development and function of many organs. Although 3D cell culture models have identified molecular mechanisms controlling lumen formation in vitro, their function during vertebrate organogenesis is poorly understood. Using light sheet microscopy and genetic approaches we have investigated single lumen formation in the zebrafish gut. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24504339
DOI: 10.1242/dev.100313
PMCID: PMC3929411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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