Article
A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.
Development (Cambridge, England) - 15 Oct 2017
Pauerstein Philip T, Tellez Krissie, Willmarth Kirk B, Park Keon Min, Hsueh Brian, Efsun Arda H, Gu Xueying, Aghajanian Haig, Deisseroth Karl, Epstein Jonathan A, Kim Seung K
Abstract excerpt
The islets of Langerhans are endocrine organs characteristically dispersed throughout the pancreas. During development, endocrine progenitors delaminate, migrate radially and cluster to form islets. Despite the distinctive distribution of islets, spatially localized signals that control islet morphogenesis have not been discovered. Here, we identify a radial signaling axis that instructs developing islet cells to...
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