Article
Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility.
Journal of medical genetics - 1 Oct 2018
Weren Robbert D A, van der Post Rachel S, Vogelaar Ingrid P, van Krieken J Han, Spruijt Liesbeth, Lubinski Jan, Jakubowska Anna, Teodorczyk Urszula, Aalfs Cora M, van Hest Liselotte P, Oliveira Carla, Kamping Eveline J, Schackert Hans K, Ranzani Guglielmina N, Gómez García Encarna B, Hes Frederik J, Holinski-Feder Elke, Genuardi Maurizio, Ausems Margreet G E M, Sijmons Rolf H, Wagner Anja, van der Kolk Lizet E, Cats Annemieke, Bjørnevoll Inga, Hoogerbrugge Nicoline, Ligtenberg Marjolijn J L
Abstract excerpt
BACKGROUND: In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1, MAP3K6 or MYD88. METHODS: We sequenced a...
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