Article
The role of multi-organ cancer predisposition genes in the risk of inherited and histologically diverse gastric cancer.
EBioMedicine - 1 Jun 2025
Guerra Joana, Estrada-Florez Ana P, Lott Paul C, Pinto Carla, Pinheiro Manuela, Chiu Katherine A, Montoya Dennis J, Zhang Hongyong, Polanco-Echeverry Guadalupe M, Pinto Pedro, Peixoto Ana, Santos Catarina, Barbosa Ana, Silva João, Suarez-Olaya John, Castro-Valencia Fabian, Molina Graciela, Corvalán Alejandro H, Della Valle Adriana, Castelao Jose E, Fernandez-Fernandez Nereida, Cid Lucia, Rios-Sarabia Nora, Medrano Rafael, Mantilla Alejandra, Echeverry de Polanco Maria M, Rivera-Herrera Ana L, Riaño-Moreno Julián, Parra-Medina Rafael, González-Castrillón Luz M, Dominguez Ricardo, Isidoro Ana R, Silva Fernanda, Morgan Douglas R, Cock-Rada Alicia M, Sanabria-Salas Maria C, Bohorquez Mabel H, Torres Javier, Teixeira Manuel R, Carvajal-Carmona Luis G
Abstract excerpt
BACKGROUND: Approximately 10% of cases with gastric cancer (GC) exhibit familial clustering, however, only 1-3% of cases can be explained by two known hereditary syndromes: Hereditary Diffuse Gastric Cancer (HDGC) caused by CDH1 and CTNNA1 pathogenic germline variants; and Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), caused by germline variants in APC 1B promoter. Familial intestinal...
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