Article
Germline mutations in MAP3K6 are associated with familial gastric cancer.
PLoS genetics - 1 Oct 2014
Gaston Daniel, Hansford Samantha, Oliveira Carla, Nightingale Mathew, Pinheiro Hugo, Macgillivray Christine, Kaurah Pardeep, Rideout Andrea L, Steele Patricia, Soares Gabriela, Huang Weei-Yuarn, Whitehouse Scott, Blowers Sarah, LeBlanc Marissa A, Jiang Haiyan, Greer Wenda, Samuels Mark E, Orr Andrew, Fernandez Conrad V, Majewski Jacek, Ludman Mark, Dyack Sarah, Penney Lynette S, McMaster Christopher R, Huntsman David, Bedard Karen
Abstract excerpt
Gastric cancer is among the leading causes of cancer-related deaths worldwide. While heritable forms of gastric cancer are relatively rare, identifying the genes responsible for such cases can inform diagnosis and treatment for both hereditary and sporadic cases of gastric cancer. Mutations in the E-cadherin gene, CDH1, account for 40% of the most common form of familial gastric cancer (FGC), hereditary diffuse...
Topics
- Antigens, CD
- Cadherins
- DNA Mutational Analysis
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- Germ-Line Mutation