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Article

Two Orangutan Species Have Evolved Different KIR Alleles and Haplotypes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2017

Guethlein Lisbeth A, Norman Paul J, Heijmans Corinne M C, de Groot Natasja G, Hilton Hugo G, Babrzadeh Farbod, Abi-Rached Laurent, Bontrop Ronald E, Parham Peter

Abstract excerpt

The immune and reproductive functions of human NK cells are regulated by interactions of the C1 and C2 epitopes of HLA-C with C1-specific and C2-specific lineage III killer cell Ig-like receptors (KIR). This rapidly evolving and diverse system of ligands and receptors is restricted to humans and great apes. In this context, the orangutan has particular relevance because it represents an evolutionary intermediate,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28264973
DOI: 10.4049/jimmunol.1602163
PMCID: PMC5438093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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