Article
miR-96 is required for normal development of the auditory hindbrain.
Human molecular genetics - 1 Mar 2018
Schlüter Tina, Berger Christina, Rosengauer Elena, Fieth Pascal, Krohs Constanze, Ushakov Kathy, Steel Karen P, Avraham Karen B, Hartmann Alexander K, Felmy Felix, Nothwang Hans Gerd
Abstract excerpt
The peripheral deafness gene Mir96 is expressed in both the cochlea and central auditory circuits. To investigate whether it plays a role in the auditory system beyond the cochlea, we characterized homozygous Dmdo/Dmdo mice with a point mutation in miR-96. Anatomical analysis demonstrated a significant decrease in volume of auditory nuclei in Dmdo/Dmdo mice. This decrease resulted from decreased cell size....
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