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Article

Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons.

Journal of neurophysiology - 1 Sept 2007

Brew Helen M, Gittelman Joshua X, Silverstein Robert S, Hanks Timothy D, Demas Vas P, Robinson Linda C, Robbins Carol A, McKee-Johnson Jennifer, Chiu Shing Yan, Messing Albee, Tempel Bruce L

Abstract excerpt

Genes Kcna1 and Kcna2 code for the voltage-dependent potassium channel subunits Kv1.1 and Kv1.2, which are coexpressed in large axons and commonly present within the same tetramers. Both contribute to the low-voltage-activated potassium current I Kv1, which powerfully limits excitability and facilitates temporally precise transmission of information, e.g., in auditory neurons of the medial nucleus of the...

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PMID: 17634333
DOI: 10.1152/jn.00640.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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