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Article

Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice.

Hearing research - 1 Jun 2020

Claußen Maike, Schulze Jennifer, Nothwang Hans Gerd

Abstract excerpt

Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory nerve. Mutations in the tight junction protein Claudin 14 cause autosomal recessive non-syndromic hearing loss (DFNB29) in humans and mice, due to extensive degeneration of outer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32251970
DOI: 10.1016/j.heares.2020.107950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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