Article

Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation

2023-10-28

Abstract excerpt

Mutations in microRNA-96 ( MIR96 ) cause dominant delayed onset hearing loss DFNA50 without treatment. Genome editing has shown efficacy in hearing recovery by intervention in neonatal mice, yet editing in the adult inner ear is necessary for clinical applications. Here, we developed an editing therapy for a C>A point mutation in the seed region of the Mir96 gene, Mir96 14C>A associated with hearing loss by s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d700eae9-0332-5bab-b19c-7df3a5d34d80
DOI: 10.1101/2023.10.26.564008

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutationDOI 10.1101/2023.10.26.564008Read

Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation.Semantic proximity Read

Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss.Semantic proximity Read

Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations.Semantic proximity Read

Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutationsSemantic proximity Read

miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells.Semantic proximity Read

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutationSemantic proximity Read

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutationSemantic proximity Read

Advances in genome editing for genetic hearing loss.Semantic proximity Read

Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function.Semantic proximity Read

A novel mutation within the MIR96 gene causes non-syndromic inherited hearing loss in an Italian family by altering pre-miRNA processing.Semantic proximity Read

Hearing impairment due to Mir183/96/182 mutations suggests both loss and gain of function effectsSemantic proximity Read

Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model.Semantic proximity Read