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Article

Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations.

Genome medicine - 21 Oct 2024

Lewis Morag A, Lachgar-Ruiz Maria, Di Domenico Francesca, Duddy Graham, Chen Jing, Fernandez Sergio, Morin Matias, Williams Gareth, Moreno Pelayo Miguel Angel, Steel Karen P

Abstract excerpt

BACKGROUND: Progressive hearing loss is a common problem in the human population with no effective therapeutics currently available. However, it has a strong genetic contribution, and investigating the genes and regulatory interactions underlying hearing loss offers the possibility of identifying therapeutic candidates. Mutations in regulatory genes are particularly useful for this, and an example is the microRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39434156
DOI: 10.1186/s13073-024-01394-5
PMCID: PMC11492784

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