Article
Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot.
Scientific reports - 10 Jan 2018
Messemaker Tobias C, van Leeuwen Selina M, van den Berg Patrick R, 't Jong Anke E J, Palstra Robert-Jan, Hoeben Rob C, Semrau Stefan, Mikkers Harald M M
Abstract excerpt
The transcription factor Sox2 controls the fate of pluripotent stem cells and neural stem cells. This gatekeeper function requires well-regulated Sox2 levels. We postulated that Sox2 regulation is partially controlled by the Sox2 overlapping long non-coding RNA (lncRNA) gene Sox2ot. Here we show that the RNA levels of Sox2ot and Sox2 are inversely correlated during neural differentiation of mouse embryonic stem...
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