Article
Sox2 acts as a transcriptional repressor in neural stem cells.
BMC neuroscience - 8 Aug 2014
Liu Yu-Ru, Laghari Zulfiqar A, Novoa Carolina A, Hughes Jaime, Webster Jamie R M, Goodwin Paul E, Wheatley Sally P, Scotting Paul J
Abstract excerpt
BACKGROUND: The transcription factor, Sox2, is central to the behaviour of neural stem cells. It is also one of the key embryonic stem cell factors that, when overexpressed can convert somatic cells into induced pluripotent cells. Although generally studied as a transcriptional activator, recent evidence suggests that it might also repress gene expression. RESULTS: We show that in neural stem cells Sox2 represses...
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