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Article

An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines.

BMC genomics - 25 Aug 2014

Vencken Sebastian F, Sethupathy Praveen, Blackshields Gordon, Spillane Cathy, Elbaruni Salah, Sheils Orla, Gallagher Michael F, O'Leary John J

Abstract excerpt

BACKGROUND: SOX2 is a core component of the transcriptional network responsible for maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self-renewal. As such, SOX2 is an oncogenic transcription factor and crucial cancer stem cell (CSC) biomarker in embryonal carcinoma and, as more recently found, in the stem-like cancer cell component of many other malignancies. SOX2 is...

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Source

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Identifiers

PMID: 25156079
DOI: 10.1186/1471-2164-15-711
PMCID: PMC4162954

Genes

SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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