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Article

Emx2 is a dose-dependent negative regulator of Sox2 telencephalic enhancers.

Nucleic acids research - 1 Aug 2012

Mariani J, Favaro R, Lancini C, Vaccari G, Ferri A L, Bertolini J, Tonoli D, Latorre E, Caccia R, Ronchi A, Ottolenghi S, Miyagi S, Okuda A, Zappavigna V, Nicolis S K

Abstract excerpt

The transcription factor Sox2 is essential for neural stem cells (NSC) maintenance in the hippocampus and in vitro. The transcription factor Emx2 is also critical for hippocampal development and NSC self-renewal. Searching for 'modifier' genes affecting the Sox2 deficiency phenotype in mouse, we...

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Source

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Identifiers

PMID: 22495934
DOI: 10.1093/nar/gks295
PMCID: PMC3413107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22495934-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Emx2 is a dose-dependent negative regulator of Sox2 telencephalic enhancers.PMID 22495934Read ↗

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The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone.Semantic proximity Read ↗

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