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Article

Exome-wide rare variant analyses of two bone mineral density phenotypes: the challenges of analyzing rare genetic variation.

Scientific reports - 9 Jan 2018

Sun Jianping, Oualkacha Karim, Forgetta Vincenzo, Zheng Hou-Feng, Richards J Brent, Evans Daniel S, Orwoll Eric, Greenwood Celia M T

Abstract excerpt

Performance of a recently developed test for association between multivariate phenotypes and sets of genetic variants (MURAT) is demonstrated using measures of bone mineral density (BMD). By combining individual-level whole genome sequenced data from the UK10K study, and imputed genome-wide genetic data on individuals from the Study of Osteoporotic Fractures (SOF) and the Osteoporotic Fractures in Men Study...

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Identifiers

PMID: 29317680
DOI: 10.1038/s41598-017-18385-9
PMCID: PMC5760616

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