Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.

The Journal of biological chemistry - 2 Mar 2018

Ko Chih-Wei, Counihan Daniel, Wu Jing, Hatzoglou Maria, Puchowicz Michelle A, Croniger Colleen M

Abstract excerpt

Phosphoenolpyruvate carboxykinase (Pck1) is a metabolic enzyme that is integral to the gluconeogenic and glyceroneogenic pathways. However, Pck1's role in macrophage metabolism and function is unknown. Using stable isotopomer MS analysis in a mouse model with a myeloid cell-specific Pck1 deletion, we show here that this deletion increases the proinflammatory phenotype in macrophages. Incubation of LPS-stimulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Glucose

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutamine

Share to Inflammation

Share to Macrophages

Share to Palmitic Acid

Share to Phosphoenolpyruvate Carboxykinase (GTP)

Share to RAW 264.7 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 29317502
DOI: 10.1074/jbc.M117.819136
PMCID: PMC5836109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.PMID 29317502Read ↗

Glycolytic side pathways regulating macrophage inflammatory phenotypes and functions.Semantic proximity Read ↗

The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.Semantic proximity Read ↗

A Comprehensive High-Efficiency Protocol for Isolation, Culture, Polarization, and Glycolytic Characterization of Bone Marrow-Derived Macrophages.Semantic proximity Read ↗

Non-invasive Differentiation of M1 and M2 Activation in Macrophages using Hyperpolarized <sup>13</sup> C MRS of Pyruvate and DHA at 1.47 TeslaSemantic proximity Read ↗

Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis.Semantic proximity Read ↗

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors.Semantic proximity Read ↗

Defining the metabolic signatures associated with human macrophage polarisation.Semantic proximity Read ↗

Methylglyoxal Drives a Distinct, Nonclassical Macrophage Activation Status.Semantic proximity Read ↗

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease.Semantic proximity Read ↗

The PI3K-Akt-CCND2 axis orchestrates macrophage M1 polarization through metabolic reprogramming: mechanistic and therapeutic insightsSemantic proximity Read ↗

Mevalonate kinase-deficient THP-1 cells show a disease-characteristic pro-inflammatory phenotype.Semantic proximity Read ↗

Macrophage metabolic regulation by phosphoglucomutase 1 shapes the host immune response in pneumococcal meningitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.