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Article

Deletion of ADA2 Increases Antifungal Drug Susceptibility and Virulence in Candida glabrata

5 Jan 2018

Abstract excerpt

ABSTRACT Candida glabrata , the second most frequent cause of candidiasis after Candida albicans , is an emerging human fungal pathogen that is intrinsically drug tolerant. Currently, studies of C. glabrata genes involved in drug tolerance are limited. Ada2, a component serving as a transcription adaptor of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex, is required for antifungal drug tolerance and virulence...

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PMID: 29311082
DOI: 10.1128/aac.01924-17

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