Article
Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence.
Eukaryotic cell - 1 Apr 2004
Kamran Mohammed, Calcagno Ana-Maria, Findon Helen, Bignell Elaine, Jones Michael D, Warn Peter, Hopkins Philip, Denning David W, Butler Geraldine, Rogers Thomas, Mühlschlegel Fritz A, Haynes Ken
Abstract excerpt
During an infection, the coordinated orchestration of many factors by the invading organism is required for disease to be initiated and to progress. The elucidation of the processes involved is critical to the development of a clear understanding of host-pathogen interactions. For Candida species, the inactivation of many fungal attributes has been shown to result in attenuation. Here we demonstrate that the...
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