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Article

Toward an Integrated Model of Capsule Regulation in Cryptococcus neoformans

8 Dec 2011

Abstract excerpt

Cryptococcus neoformans is an opportunistic fungal pathogen that causes serious human disease in immunocompromised populations. Its polysaccharide capsule is a key virulence factor which is regulated in response to growth conditions, becoming enlarged in the context of infection. We used microarray analysis of cells stimulated to form capsule over a range of growth conditions to identify a transcriptional...

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PMID: 22174677
DOI: 10.1371/journal.ppat.1002411

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