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Article

Genetically Encoded Glutamate Indicators with Altered Color and Topology.

ACS chemical biology - 20 Jul 2018

Wu Jiahui, Abdelfattah Ahmed S, Zhou Hang, Ruangkittisakul Araya, Qian Yong, Ballanyi Klaus, Campbell Robert E

Abstract excerpt

Glutamate is one of the 20 common amino acids and of utmost importance for chemically mediated synaptic transmission in nervous systems. To expand the color palette of genetically encoded indicators for glutamate, we used protein engineering to develop a red intensity-based glutamate-sensing fluorescent reporter (R-iGluSnFR1). Manipulating the topology of R-iGluSnFR1, and a previously reported green fluorescent...

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PMID: 29308878
DOI: 10.1021/acschembio.7b01085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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