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Article

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.

Gastroenterology - 1 Apr 2018

Du Kuo, Hyun Jeongeun, Premont Richard T, Choi Steve S, Michelotti Gregory A, Swiderska-Syn Marzena, Dalton George D, Thelen Eric, Rizi Bahar Salimian, Jung Youngmi, Diehl Anna Mae

Abstract excerpt

BACKGROUND & AIMS: Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted. Hedgehog signaling promotes transdifferentiation of HSCs by activating Yes-associated protein 1 (YAP1 or YAP) and inducing aerobic glycolysis. However, increased aerobic glycolysis alone cannot meet the high metabolic demands of...

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Source

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Identifiers

PMID: 29305935
DOI: 10.1053/j.gastro.2017.12.022
PMCID: PMC5880682

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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