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Article

Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers.

Cells - 4 May 2022

Sohn Hyun Ahm, Lee Dong Chul, Park Anna, Kang Minho, Yoon Byoung-Ha, Lee Chul-Ho, Kim Yong-Hoon, Oh Kyoung-Jin, Kim Cha Yeon, Park Seong-Hwan, Koo Han, Kim Hyoung-Chin, Yoon Won Kee, Lim Dae-Sik, Kim Daesoo, Park Kyung Chan, Yeom Young Il

Abstract excerpt

N-Myc downstream regulated gene 3 (NDRG3) is a unique pro-tumorigenic member among NDRG family genes, mediating growth signals. Here, we investigated the pathophysiological roles of NDRG3 in relation to cell metabolism by disrupting its functions in liver. Mice with liver-specific KO of NDRG3 (Ndrg3 LKO) exhibited glycogen storage disease (GSD) phenotypes including excessive hepatic glycogen accumulation,...

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Identifiers

PMID: 35563842
DOI: 10.3390/cells11091536
PMCID: PMC9103136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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