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An analysis pipeline for understanding 6-thioguanine effects on a mouse tumour genome.

Cancer immunology, immunotherapy : CII - 27 Jan 2024

Yankilevich Patricio, Nazerai Loulieta, Willis Shona Caroline, Schmiegelow Kjeld, De Zio Daniela, Nielsen Morten

Abstract excerpt

Mouse tumour models are extensively used as a pre-clinical research tool in the field of oncology, playing an important role in anticancer drugs discovery. Accordingly, in cancer genomics research, the demand for next-generation sequencing (NGS) is increasing, and consequently, the need for data analysis pipelines is likewise growing. Most NGS data analysis solutions to date do not support mouse data or require...

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PMID: 38279992
DOI: 10.1007/s00262-023-03610-4
PMCID: PMC10821971

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