Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats.

doi:10.1097/HJH.0000000000001654

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Article

Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats.

Journal of hypertension - 1 May 2018

Ling Li, Chen Dan, Tong Ying, Zang Ying-Hao, Ren Xing-Sheng, Zhou Hong, Qi Xiao-Hong, Chen Qi, Li Yue-Hua, Kang Yu-Ming, Zhu Guo-Qing

Abstract excerpt

OBJECTIVE: Phenotypic transformation of adventitial fibroblasts is important in the pathogenesis of hypertension. This study was designed to determine whether fibronectin type III domain containing 5 (FNDC5) alleviates the phenotypic transformation of adventitial fibroblasts in hypertension and the underlying mechanisms. METHODS AND RESULTS: Experiments were carried out in spontaneously hypertensive rats (SHR)...

Read the complete abstract on PubMed

Topics

Adventitia
Animals
Aorta
Blood Pressure
Extracellular Matrix
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibronectins

Hypertension

Inflammasomes

Male

NADPH Oxidase 2

NLR Family, Pyrin Domain-Containing 3 Protein

Phenotype

Rats

Rats, Inbred SHR

Rats, Inbred WKY

Reactive Oxygen Species

Vascular Remodeling

Source

Open in PubMed

Identifiers

PMID: 29303830
DOI: 10.1097/HJH.0000000000001654

Genes

FNDC5
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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