Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations

13 May 2025

Abstract excerpt

Thoracic aortopathy is influenced by angiotensin II (AngII) and exhibits regional heterogeneity with the ascending aorta being particularly susceptible. In this region, smooth muscle cells (SMCs) and selected fibroblasts originate from the second heart field (SHF) and cardiac neural crest (CNC). While our previous study revealed a critical role of SHF-derived cells in AngII-mediated aortopathy, the contribution...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Disease and Treatment Approaches
Share to Congenital heart defects research
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40360730
DOI: 10.1038/s41598-025-99862-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterationsPMID 40360730Read ↗

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending AortopathiesSemantic proximity Read ↗

KLF4 in smooth muscle cell-derived progenitor cells is essential for angiotensin II-induced cardiac inflammation and fibrosisSemantic proximity Read ↗

KLF4 in Smooth Muscle Cell–Derived Progenitor Cells Is Essential for Angiotensin II–Induced Cardiac Inflammation and FibrosisSemantic proximity Read ↗

Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling DisruptionSemantic proximity Read ↗

Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic AneurysmSemantic proximity Read ↗

Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic AneurysmsSemantic proximity Read ↗

Single-cell lineage tracing unveils sex differences in VSMCs derived from the cardiac neural crest and second heart field.Semantic proximity Read ↗

Cardiac and perivascular myofibroblasts, matrifibrocytes, and immune fibrocytes in hypertension; commonalities and differences with other cardiovascular diseases.Semantic proximity Read ↗

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndromeSemantic proximity Read ↗

Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta-Brief Report.Semantic proximity Read ↗

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodelingSemantic proximity Read ↗

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell levelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.