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Article

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

The Journal of clinical endocrinology and metabolism - 1 Aug 2018

Koskinen Maarit K, Lempainen Johanna, Löyttyniemi Eliisa, Helminen Olli, Hekkala Anne, Härkönen Taina, Kiviniemi Minna, Simell Olli, Knip Mikael, Ilonen Jorma, Toppari Jorma, Veijola Riitta

Abstract excerpt

Context: A declining first-phase insulin response (FPIR) is characteristic of the disease process leading to clinical type 1 diabetes. It is not known whether reduced FPIR depends on class II human leukocyte antigen (HLA) genotype, islet autoimmunity, or both. Objective: To dissect the role of class II HLA DR-DQ genotypes and biochemical islet autoantibodies in the compromised FPIR. Design, Setting, Participants:...

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Source

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Identifiers

PMID: 29300921
DOI: 10.1210/jc.2017-02040
PMCID: PMC6097602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.PMID 29300921Read ↗

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