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Article

Reduced β-cell function in early preclinical type 1 diabetes.

European journal of endocrinology - 1 Mar 2016

Koskinen Maarit K, Helminen Olli, Matomäki Jaakko, Aspholm Susanna, Mykkänen Juha, Mäkinen Marjaana, Simell Ville, Vähä-Mäkilä Mari, Simell Tuula, Ilonen Jorma, Knip Mikael, Veijola Riitta, Toppari Jorma, Simell Olli

Abstract excerpt

OBJECTIVE: We aimed to characterize insulin responses to i.v. glucose during the preclinical period of type 1 diabetes starting from the emergence of islet autoimmunity. DESIGN AND METHODS: A large population-based cohort of children with HLA-conferred susceptibility to type 1 diabetes was observed from birth. During regular follow-up visits islet autoantibodies were analysed. We compared markers of glucose...

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Share to Autoantibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Glucose Tolerance Test

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Share to Insulin Secretion

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Source

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Identifiers

PMID: 26620391
DOI: 10.1530/EJE-15-0674
PMCID: PMC4712442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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