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Article

Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes.

Diabetes - 1 Dec 2010

Lipponen Kati, Gombos Zsofia, Kiviniemi Minna, Siljander Heli, Lempainen Johanna, Hermann Robert, Veijola Riitta, Simell Olli, Knip Mikael, Ilonen Jorma

Abstract excerpt

OBJECTIVE: Class II alleles define the main HLA effect on type 1 diabetes, but there is an independent effect of certain class I alleles. Class II and class I molecules are differently involved in the initiation and effector phases of the immune response, suggesting that class I alleles would be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20739684
DOI: 10.2337/db10-0167
PMCID: PMC2992790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20739684-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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