Article
Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.
The Journal of experimental medicine - 18 Nov 2013
Muto Tomoya, Sashida Goro, Oshima Motohiko, Wendt George R, Mochizuki-Kashio Makiko, Nagata Yasunobu, Sanada Masashi, Miyagi Satoru, Saraya Atsunori, Kamio Asuka, Nagae Genta, Nakaseko Chiaki, Yokote Koutaro, Shimoda Kazuya, Koseki Haruhiko, Suzuki Yutaka, Sugano Sumio, Aburatani Hiroyuki, Ogawa Seishi, Iwama Atsushi
Abstract excerpt
Polycomb group (PcG) proteins are essential regulators of hematopoietic stem cells. Recent extensive mutation analyses of the myeloid malignancies have revealed that inactivating somatic mutations in PcG genes such as EZH2 and ASXL1 occur frequently in patients with myelodysplastic disorders including myelodysplastic syndromes (MDSs) and MDS/myeloproliferative neoplasm (MPN) overlap disorders (MDS/MPN). In our...
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