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Article

[Pathogenic role of insufficiency of polycomb repressive complex in primary myelofibrosis].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2023

Shinoda Daisuke

Abstract excerpt

Primary myelofibrosis (PMF) is characterized by the clonal expansion of megakaryocytes and myeloid cells from stem cells with abnormal cytokine expression, resulting in bone marrow fibrosis, angiogenesis, and osteosclerosis. The use of next-generation sequencing revealed that both genetic and epigenetic changes are important in the pathogenesis of PMF. Several epigenetic regulator genes, including TET2, the...

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PMID: 37793876
DOI: 10.11406/rinketsu.64.998

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