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Article

Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity.

Clinical chemistry - 1 Jan 2018

Astley Christina M, Todd Jennifer N, Salem Rany M, Vedantam Sailaja, Ebbeling Cara B, Huang Paul L, Ludwig David S, Hirschhorn Joel N, Florez Jose C

Abstract excerpt

BACKGROUND: A fundamental precept of the carbohydrate-insulin model of obesity is that insulin secretion drives weight gain. However, fasting hyperinsulinemia can also be driven by obesity-induced insulin resistance. We used genetic variation to isolate and estimate the potentially causal effect of insulin secretion on body weight. METHODS: Genetic instruments of variation of insulin secretion [assessed as...

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Share to Body Mass Index
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29295838
DOI: 10.1373/clinchem.2017.280727
PMCID: PMC5937525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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