Article
Genetics of glucose homeostasis: implications for insulin resistance and metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2012
Norris Jill M, Rich Stephen S
Abstract excerpt
This review summarizes the current understanding of the genetic basis of glucose homeostasis through genome-wide association scans and candidate gene studies of case-control and family-based designs. We highlight the implications of phenotype-direct (euglycemic clamp or frequently sampled intravenous glucose tolerance test) and indirect (fasting insulin and fasting glucose) measures on the determinants of insulin...
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